Involvement of toll-like receptor 9 polymorphism in cervical cancer development
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چکیده
منابع مشابه
Toll-Like Receptor 9 in Breast Cancer
Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system. DNA recognition via TLR9 results in an inflammatory reaction, which eventually also activates a Th1-biased adaptive immune attack. In addition to cells of the immune system, TLR9 mRNA and protein are also widely expressed in breast cancer cell lines and in clinical breast cancer specimens. Although synthetic TLR...
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Common variable immunodefi ciency (CVID) is a primary immunodeficiency involving a heterogeneous group of disorders characterized by recurrent bacterial infections and defi cient production of different classes of antibodies. The predisposing genetic factors associated with CVID remain unknown [1], although homozygous defects in ICOS or CD19 have been detected in a very small number of patients...
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The immune system has acquired increasing importance as a key player in cancer maintenance and growth. Thus, modulating anti-tumor immune mediators has become an attractive strategy for cancer treatment. Toll-like receptors (TLRs) have gradually emerged as potential targets of newer immunotherapies. TLR-9 is preferentially expressed on endosome membranes of B-cells and plasmacytoid dendritic ce...
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Objective: Silymarin is a herbal extract containing flavonolignans, and it has inhibitory effects against the growth of different cancer cell lines by inducing apoptosis. Toll-like receptors are suggested as a novel and attractive target to treat cancer. The current study aimed at examining the mechanism of silymarin-induced apoptosis in Ramos cells and investigating its effect...
متن کاملThe Role of Toll-Like Receptors in Breast Cancer
Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...
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ژورنال
عنوان ژورنال: Molecular Biology Reports
سال: 2012
ISSN: 0301-4851,1573-4978
DOI: 10.1007/s11033-012-1695-8